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Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma.
Plain-language guide to PMID 25617224 (2015): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 44 patients.
Key Facts
- PMID
- 25617224
- Journal
- The Journal of allergy and clinical immunology
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- de Groot JC et al. (8 authors)
- DOI
- 10.1016/j.jaci.2014.11.033
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The researchers sought to evaluate the effect of vitamin D supplementation on eosinophilic and neutrophilic airway inflammation in patients with nonatopic asthma.
Who Took Part
According to the abstract, 44 patients were involved.
PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.
Other measurements included questionnaires, blood samples, and pulmonary function.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
What Was Measured
Topics PubMed links to this paper include Asthma, Cholecalciferol, Eosinophils, Neutrophils, Pulmonary Eosinophilia, Respiratory Function Tests and Respiratory System.
The authors tagged it with the keywords airway inflammation, nonatopic and vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 44 patients.
Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2015 (The Journal of allergy and clinical immunology), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.