Increase Trend in Home Blood Pressure on a Single Occasion Is Associated With B-Type Natriuretic Peptide and the Estimated Glomerular Filtration Rate

What Was Tested

The paper reports a study of BNP (Nesiritide) in the context of low blood pressure and orthostatic hypotension, published as an observational study.

Although obtaining multiple home blood pressure (HBP) measurements on a single occasion was recommended in European and Japanese hypertension guidelines, the clinical implications of the differences in BP measurements on a single occasion have been uncertain.

Who Took Part

The study group was 4,149 patients.

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

Here, 4,149 patients with cardiovascular risk factors were enrolled.

The associations between TOD and the difference between the first home systolic BP (SBP) value and the average of the second and third home SBP values were assessed by multiple regression analyses with adjustment for covariates.

How the Study Was Run

The researchers evaluated the target organ damage (TOD) indicators left ventricular mass index (LVMI), urinary albumin creatinine ratio, B-type natriuretic peptide (BNP), N-terminal pro-BNP (NT-pro BNP), high-sensitive cardiac troponin, brachial-ankle pulse wave velocity (ba PWV), intima-media thickness, and estimated glomerular filtration rate (eGFR).

What Was Measured

Although obtaining multiple home blood pressure (HBP) measurements on a single occasion was recommended in European and Japanese hypertension guidelines, the clinical implications of the differences in BP measurements on a single occasion have been uncertain.

PubMed files the paper under topics including Biomarkers, Blood Pressure, Blood Pressure Determination, Disease Progression, Glomerular Filtration Rate, Heart Diseases and Hypertension.

Author keywords: home blood pressure, multiple measurements on a single occasion and target organ damage.

What This Means in Plain Language

This is an observational study of BNP (Nesiritide) in 4,149 patients in people with low blood pressure and orthostatic hypotension.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (American journal of hypertension), a journal based in United States.

More context: the BNP (Nesiritide) compound page, Low blood pressure and orthostatic hypotension research.