Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance

What Was Tested

The paper reports a study of Ghrelin in the context of insulin resistance, prediabetes & type 2 diabetes, published as a randomized controlled trial.

Fructose consumption has risen alongside obesity and diabetes.

Gut hormones involved in hunger and satiety (ghrelin and PYY) may respond differently to fructose compared with glucose ingestion.

This study evaluated the effects of glucose and fructose ingestion on ghrelin and PYY in lean and obese adolescents with differing insulin sensitivity.

Who Took Part

PubMed indexes the participants as teenagers, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and crossover study.

The participants were allocated by chance, so the Ghrelin group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Ghrelin.

In the crossover set-up each of the participants took both Ghrelin and the comparison in turn, acting as their own control.

Adolescents were divided into lean (n = 14), obese insulin sensitive (n = 12) (OIS), and obese insulin resistant (n = 15) (OIR).

What Was Measured

Topics PubMed links to this paper include Acylation, Eating, Fructose, Gastrointestinal Hormones, Ghrelin, Glucose and Hunger.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of Ghrelin in people with insulin resistance, prediabetes & type 2 diabetes.

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2015 (Obesity (Silver Spring, Md.)), a journal based in United States.

More context: the Ghrelin compound page, Insulin resistance, prediabetes & type 2 diabetes research.