The effect of calcium plus vitamin D supplementation on the risk of venous thromboembolism. From the Women's Health Initiative Randomized Controlled Trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

This secondary analysis of the trial compared the incidence of VTE by treatment group using an intention-to-treat Cox regression analysis.

Who Took Part

The abstract describes 36,282 women taking part.

The age groups tagged for this paper are middle-aged adults and older adults, women only.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some women received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

What Was Measured

This secondary analysis of the trial compared the incidence of VTE by treatment group using an intention-to-treat Cox regression analysis.

PubMed files the paper under topics including Calcium Carbonate, Colorectal Neoplasms, Dietary Supplements, Hip Fractures, Proportional Hazards Models, Venous Thromboembolism and Vitamin D.

Author keywords: Venous thrombosis, clinical studies and risk factors.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 36,282 women.

With several hundred people or more, it is a fairly large study for this kind of research.

The publication is from 2015 (Thrombosis and haemostasis), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.