Efficacy and safety investigation of Kuntai capsule for the add-back therapy of gonadotropin releasing hormone agonist administration to endometriosis patients: a randomized, double-blind, blank- and tibolone-controlled study

What Was Tested

This randomized controlled trial paper looks at Goserelin in the context of endometriosis.

But it is still not clear whether Kuntai capsule has a good effect on alleviating peri-menopausal symptoms induced by gonadotropin releasing hormone agonist (GnRH-a) treatment.

Who Took Part

The age groups tagged for this paper are young adults and adults, women only.

Ninety EMS ovarian cyst women with postoperative GnRH-a administration were enrolled in the study, and were randomly divided into Kuntai group, Tibolone group, or blank Control group.

Climacteric complaints were evaluated by Kupperman menopausal index (KMI) and hot flash/sweating score.

How the Study Was Run

The design is described as randomized and double-blind.

Because people in this Goserelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Goserelin study, the assignments were hidden from both participants and investigators until the end.

There was no drug addition in Control group.

Liver and renal functions, lipid profile, serum sex hormone levels and endometrial thickness were measured, and the frequency of adverse events in Kuntai and Tibolone groups was recorded.

What Was Measured

PubMed files the paper under topics including Drugs, Chinese Herbal, Endometriosis, Endometrium, Gonadotropin-Releasing Hormone, Goserelin and Norpregnenes.

What This Means in Plain Language

The paper is a randomized and double-blind study of Goserelin in people with endometriosis.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2015 (Chinese medical journal), a journal based in China.

More context: the Goserelin compound page, Endometriosis research.