ω-3 fatty acid differentially modulated serum levels of IGF1 and IGFBP3 in men with CVD: a randomized, double-blind placebo-controlled study.

What Was Tested

Researchers studied Fatty Acids, Omega-3 in this randomized controlled trial publication.

Studies have reported elevated serum insulin-like growth factor (IGF)-1 levels followed by ω-3 supplementation in various groups.

Who Took Part

PubMed indexes the participants as middle-aged adults, men only.

Sixty-two middle-aged (55.9 ± 6.5 y) non-obese men with CVD followed the study protocol in two groups of ω-3 (n = 31) or placebo (n = 31) supplementation.

Anthropometric and lipid profile characteristics, serum IGF1, serum IGFBP3 and also IGF1 and IGFBP3 gene expression in peripheral blood mononuclear cells (PBMCs) were measured in all participants before and after the intervention.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Fatty Acids, Omega-3 study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Fatty Acids, Omega-3 study, the assignments were hidden from both participants and investigators until the end.

Some participants received a placebo instead of Fatty Acids, Omega-3, giving a reference point.

Statistical analyses were performed using SPSS software.

What Was Measured

Topics PubMed links to this paper include Body Mass Index, Cardiovascular Diseases, Dietary Supplements, Fatty Acids, Omega-3, Gene Expression, Insulin-Like Growth Factor Binding Protein 3 and Insulin-Like Growth Factor I.

Author keywords: IGF1, IGFBP3 and ω-3.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Fatty Acids, Omega-3.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (Nutrition (Burbank, Los Angeles County, Calif.)), a journal based in United States.

More context: all human trials.