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Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial
Plain-language guide to PMID 25712255 (2015): double-blind randomized controlled trial study of Cyanocobalamin (Vitamin B12) in 1111 participants.
Key Facts
- PMID
- 25712255
- Journal
- Calcified tissue international
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Enneman AW et al. (16 authors)
- DOI
- 10.1007/s00223-015-9968-6
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
However, the mechanism remains unclear.
The researchers investigated the effect of Hcy-lowering vitamin B12 and folic acid treatment on bone mineral density (BMD) and calcaneal quantitative ultrasound (QUS) parameters.
Who Took Part
According to the abstract, 1111 participants were involved.
PubMed indexes the participants as older adults and people over 80, both men and women.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.
As a double-blind Cyanocobalamin (Vitamin B12) study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with Cyanocobalamin (Vitamin B12) could be set against what happens without it.
The timeline in the abstract includes 2 years.
What Was Measured
This randomized, double-blind, placebo-controlled trial included participants aged ≥65 years with plasma Hcy levels between 12 and 50 µmol/L.
In total, 1111 participants underwent repeated dual-energy X-ray assessment and 1165 participants underwent QUS.
Topics PubMed links to this paper include Absorptiometry, Photon, Bone Density, Calcaneus, Dietary Supplements, Femur Neck, Folic Acid and Homocysteine.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 1111 participants over 2 years.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2015 (Calcified tissue international), a journal based in United States.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.