Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus.

What Was Tested

This clinical trial looks at Vitamin D, K2, Magnesium and Zinc.

Who Took Part

According to the abstract, 112 patients were involved.

PubMed indexes the participants as adults, middle-aged adults, older adults and people over 80, both men and women.

This prospective, placebo-controlled trial included 112 type 2 diabetic patients with diabetic peripheral neuropathy (DPN) and vitamin D [25(OH)D] deficiency.

Patients were sequentially assigned to a treatment group (n = 57) and a placebo group (n = 55).

How the Study Was Run

The researchers set it up as a double-blind and placebo-controlled study.

Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

DPN was assessed using a neuropathy symptom score (NSS), a neuropathy disability score (NDS) and a nerve conduction study (NCS).

Vitamin D status was determined by measuring the serum total 25(OH)D concentration.

The primary outcome was changes in NSS and NDS from baseline.

The secondary outcome was changes in the NCS result.

What Was Measured

The subject headings attached to it are Cholecalciferol, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Dietary Supplements and Disability Evaluation.

What This Means in Plain Language

The paper is a double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 112 patients.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (Medical principles and practice : international journal of the Kuwait University, Health Science Centre), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.