← Human Trials & Peer-Reviewed Studies
Circulating IGF-1 may mediate improvements in haemoglobin associated with vitamin A status during pregnancy in rural Nepalese women
Plain-language guide to PMID 25740751 (2015): double-blind randomized controlled trial study of IGF-1 LR3 in 589 women.
Key Facts
- PMID
- 25740751
- Journal
- Asia Pacific journal of clinical nutrition
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Arguello MA et al. (7 authors)
- DOI
- 10.6133/apjcn.2015.24.1.12
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of IGF-1 LR3, published as a randomized controlled trial.
The aim of this study was to examine the relationship between serum retinol, IGF-1, and Hb among pregnant women in extant samples collected during a placebo-controlled trial of VA and beta-carotene (BC) supplementation in rural Nepal conducted from 1994 to 1997.
Why It Was Studied
Pregnancy exacerbates vitamin A (VA) deficiency and anaemia among women in developing countries.
Associations of IGF-1 with retinol, Hb or anaemia, and iron status were determined using multiple linear and logistic regression.
Who Took Part
According to the abstract, 589 women were involved.
PubMed indexes the participants as young adults and adults, women only.
Mid-pregnancy serum IGF-1 was measured in serum from n=589 randomly selected women of n=1186 in whom anthropometric, VA (retinol) and iron (Hb, erythrocyte zinc protoporphyrin (ZP), and ferritin) status data were available.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The women were allocated by chance, so the IGF-1 LR3 group and the comparison group should start out alike.
Neither the women nor the staff measuring them knew who was on IGF-1 LR3, so expectations could not easily colour the readings.
Some women received a placebo instead of IGF-1 LR3, giving a reference point.
What Was Measured
Topics PubMed links to this paper include Anemia, Dietary Supplements, Erythropoiesis, Ferritins, Gestational Age, Hemoglobins and Insulin-Like Growth Factor I.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of IGF-1 LR3 in 589 women.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2015 (Asia Pacific journal of clinical nutrition), a journal based in China.
More context: the IGF-1 LR3 compound page, all human trials.
Our Notes on the Compound
IGF-1 LR3: A modified IGF-1 analog that escapes binding proteins, so it stays active ≥24 h.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.