Effect of Zinc Supplementation on GH, IGF1, IGFBP3, OCN, and ALP in Non-Zinc-Deficient Children.

What Was Tested

Researchers studied Zinc in this randomized controlled trial publication.

Because most publications on growth and development deal with children with zinc deficiency, the researchers decided to study the effects of this micronutrient on the secretion of growth hormone (GH), insulin-like growth factor 1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3), osteocalcin (OCN), and alkaline phosphatase (ALP) in healthy and eutrophic children.

This study is original because the methodology was unique.

Who Took Part

By PubMed's age tags, the people studied were children, both men and women.

Forty schoolchildren participated in the study, 17 females and 23 males, aged 8 and 9 years.

All schoolchildren were also submitted to anthropometric, clinical, and dietetic assessments as well as biochemistry analyses.

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the Zinc group and the comparison group should start out alike.

It was characterized as a triple-blind randomized controlled trial.

Blood samples were collected at 0, 60, 120, 180, and 210 min.

What Was Measured

PubMed files the paper under topics including Alkaline Phosphatase, Dietary Supplements, Healthy Volunteers, Human Growth Hormone, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I and Osteocalcin.

Author keywords: GH-IGF1 system, children, oral zinc supplementation and venous zinc administration.

What This Means in Plain Language

The paper is a randomized study of Zinc.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2015 (Journal of the American College of Nutrition), a journal based in United States.

More context: all human trials.