← Human Trials & Peer-Reviewed Studies
Serum Vitamin D levels and Vitamin D supplementation do not correlate with the severity of chronic eczema in children.
Plain-language guide to PMID 25781193 (2015): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 89 children, eczema.
Key Facts
- PMID
- 25781193
- Journal
- European annals of allergy and clinical immunology
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Galli E et al. (6 authors)
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of eczema, published as a randomized controlled trial.
The purpose of their study was to assess the 25-Hydroxyvitamin D serum levels in a pediatric population suffering from chronic eczema (IgE-mediated and non-IgE-mediated), and to correlate these phenotypes with the SCORAD severity and selected clinical and biological parameters.
Moreover, the researchers aimed to evaluate whether a supplementation of Vitamin D3 could affect the same clinical and laboratory parameters.
Why It Was Studied
The pathogenic mechanisms of eczema are still not fully understood, and current treatment of moderate-severe eczema is often difficult.
Who Took Part
The study group was 89 children.
By PubMed's age tags, the people studied were infants, young children, children and teenagers, both men and women.
89 children with chronic eczema were enrolled in the study.
Past and present history was taken, and patients were divided into two groups according to the state of sensitization.
How the Study Was Run
The design is described as randomized.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Severity of eczema was assessed with the SCORAD index.
What Was Measured
The subject headings attached to it are Age Factors, Biomarkers, Calcifediol, Chronic Disease, Dietary Supplements, Eczema and Immunoglobulin E.
Author keywords: IgE chronic eczema, Not-IgE chronic eczema, Serum vitamin D levels and Vit D supplementation.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 89 children in people with eczema.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2015 (European annals of allergy and clinical immunology), a journal based in Italy.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Eczema research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.