← Human Trials & Peer-Reviewed Studies
A 24-month prospective study on the efficacy and safety of two different monthly regimens of vitamin D supplementation in pre-menopausal women with systemic lupus erythematosus.
Plain-language guide to PMID 25801893 (2015): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 34 women, lupus (sle).
Key Facts
- PMID
- 25801893
- Journal
- Lupus
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Andreoli L et al. (7 authors)
- DOI
- 10.1177/0961203314559089
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of lupus (sle) in this randomized controlled trial publication.
Low vitamin D (vit.D) serum levels are common in patients with systemic lupus erythematosus (SLE) and seem to correlate with higher disease activity.
The researchers investigated the effects of different regimens of vit.D supplementation in SLE patients with inactive disease.
Who Took Part
The study group was 34 women.
The age groups tagged for this paper are young adults and adults, women only.
Patients were seen quarterly for assessment of 25-OH vit.D levels, disease activity, SLE serology and bone metabolism markers.
How the Study Was Run
The design is described as randomized.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
What Was Measured
Low vitamin D (vit.D) serum levels are common in patients with systemic lupus erythematosus (SLE) and seem to correlate with higher disease activity.
Topics PubMed links to this paper include Cholecalciferol, Dietary Supplements, Lupus Erythematosus, Systemic, Premenopause, Vitamin D and Vitamins.
The authors tagged it with the keywords 25-OH vitamin D, Systemic lupus erythematosus (SLE) and cholecalcipherol.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 34 women in people with lupus (sle).
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2015 (Lupus), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Lupus (SLE) research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.