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Two Years of Cinacalcet Hydrochloride Treatment Decreased Parathyroid Gland Volume and Serum Parathyroid Hormone Level in Hemodialysis Patients With Advanced Secondary Hyperparathyroidism
Plain-language guide to PMID 25851690 (2015): observational study of Parathyroid Hormone (PTH 1-84) in 60 patients, hyperparathyroidism.
Key Facts
- PMID
- 25851690
- Journal
- Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
- Year
- 2015
- Study type
- Observational Study
- Authors
- Yamada S et al. (10 authors)
- DOI
- 10.1111/1744-9987.12292
What This Study Did, in Plain Language
What Was Tested
This observational study looks at Parathyroid Hormone (PTH 1-84) in the context of hyperparathyroidism.
The present study was a prospective observational study to determine the effect of cinacalcet treatment on PTG volume and serum biochemical parameters in 60 patients with renal SHPT, already treated with intravenous vitamin D receptor activator (VDRA).
Why It Was Studied
The long-term effect of cinacalcet hydrochloride treatment on parathyroid gland (PTG) volume has been scarcely investigated in patients with moderate to advanced secondary hyperparathyroidism (SHPT).
Measurement of biochemical parameters and PTG volumes were performed periodically, which were analyzed by stratification into tertiles across the baseline parathyroid hormone (PTH) level or PTG volume.
Who Took Part
The study group was 60 patients.
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
What Was Measured
The long-term effect of cinacalcet hydrochloride treatment on parathyroid gland (PTG) volume has been scarcely investigated in patients with moderate to advanced secondary hyperparathyroidism (SHPT).
Measurement of biochemical parameters and PTG volumes were performed periodically, which were analyzed by stratification into tertiles across the baseline parathyroid hormone (PTH) level or PTG volume.
Topics PubMed links to this paper include Calcimimetic Agents, Cinacalcet, Hyperparathyroidism, Secondary, Japan, Kidney Failure, Chronic, Organ Size and Parathyroid Glands.
Author keywords: Hemodialysis, Parathyroid hormone and Secondary hyperparathyroidism.
What This Means in Plain Language
This is an observational study of Parathyroid Hormone (PTH 1-84) in 60 patients in people with hyperparathyroidism.
The publication is from 2015 (Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy), a journal based in Australia.
More context: the Parathyroid Hormone (PTH 1-84) compound page, Hyperparathyroidism research.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.