Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans

What Was Tested

The paper reports a study of Insulin (regular human) in the context of insulin resistance, prediabetes & type 2 diabetes, published as a randomized controlled trial.

The aim of this study was to evaluate the influence of EPA and DHA on insulin sensitivity, insulin secretion, and muscle mitochondrial function in insulin-resistant, nondiabetic humans using a robust study design and gold-standard measurements.

Hyperinsulinemic-euglycemic clamp with somatostatin was used to assess hepatic and peripheral insulin sensitivity.

Who Took Part

PubMed indexes the participants as adults, men only.

Measurements were performed at baseline and after 6 months of treatment.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Insulin (regular human) group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Insulin (regular human).

Some participants received a placebo instead of Insulin (regular human), giving a reference point.

The timeline in the abstract includes 6 months.

Postprandial glucose disposal and insulin secretion were measured after a meal.

Abdominal fat distribution was evaluated by MRI.

Muscle oxidative capacity was measured in isolated mitochondria using high-resolution respirometry and noninvasively by magnetic resonance spectroscopy.

What Was Measured

PubMed files the paper under topics including Antimetabolites, Blood Glucose, Deoxyglucose, Docosahexaenoic Acids, Eicosapentaenoic Acid, Glucose Clamp Technique and Hypoglycemic Agents.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Insulin (regular human) in people with insulin resistance, prediabetes & type 2 diabetes over 6 months.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (Diabetes care), a journal based in United States.

More context: the Insulin (regular human) compound page, Insulin resistance, prediabetes & type 2 diabetes research.