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Immune Function and Muscle Adaptations to Resistance exercise in Older Adults: Study Protocol for a Randomized Controlled Trial of a Nutritional Supplement.
Plain-language guide to PMID 25872570 (2015): double-blind randomized controlled trial.
Key Facts
- PMID
- 25872570
- Journal
- Trials
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Dennis RA et al. (10 authors)
- DOI
- 10.1186/s13063-015-0631-3
- Registered trial
- NCT02261961
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at the intervention named in the title.
Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss.
The current study will determine the relationship between immune function and exercise training outcomes for older adults who consume a nutritional supplement or placebo during resistance training and post-training follow-up.
Who Took Part
PubMed indexes the participants as middle-aged adults, older adults and people over 80.
Participants will undergo nine blood draws and five muscle (vastus lateralis) biopsies so that the effects of the supplement on immune function and the systemic and cellular responses to exercise can be measured.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the intervention group and the comparison group should start out alike.
As a double-blind study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with the intervention named in the title could be set against what happens without it.
Analyses of the results for these objectives will determine the relationship between immune function and the training outcomes.
What Was Measured
The current study will determine the relationship between immune function and exercise training outcomes for older adults who consume a nutritional supplement or placebo during resistance training and post-training follow-up.
PubMed files the paper under topics including Adaptation, Physiological, Clinical Protocols, Dietary Supplements, Immune System, Muscle, Skeletal and Resistance Training.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study.
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2015 (Trials), a journal based in England.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.