Effect of desmopressin administration on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery: a randomized, clinical trial

What Was Tested

This randomized controlled trial paper looks at Vasopressin and Desmopressin.

This study aimed to evaluate the effect of desmopressin premedication on blood loss and the quality of the surgical field in endoscopic sinus surgery.

Why It Was Studied

Bleeding during functional endoscopic sinus surgery is a challenge for the quality of the surgical field for surgeons.

Who Took Part

By PubMed's age tags, the people studied were young adults, adults and middle-aged adults, both men and women.

A total of 90 American Society of Anesthesiologists physical status I-II patients underwent endoscopic sinus surgery for chronic sinusitis.

Management of anesthesia was achieved with propofol and remifentanil infusions, with moderate, controlled hypotension.

How the Study Was Run

The researchers set it up as a randomized and single-blind study.

Random assignment meant chance, not the researchers, decided who got Vasopressin and who got the comparison, which limits bias.

Only one side, usually the participants, was kept unaware of whether Vasopressin was given.

Blood loss and quality of the surgical field were assessed after surgery.

Effects of desmopressin on anesthetic requirements and hemodynamic variables were analyzed.

What Was Measured

PubMed files the paper under topics including Blood Loss, Surgical, Deamino Arginine Vasopressin, Endoscopy, Hemostatics, Piperidines, Propofol and Remifentanil.

What This Means in Plain Language

The paper is a randomized and single-blind study of Vasopressin and Desmopressin.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (BMC anesthesiology), a journal based in England.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.