Fortification of Yogurts with Vitamin D and Calcium Enhances the Inhibition of Serum Parathyroid Hormone and Bone Resorption Markers: A Double Blind Randomized Controlled Trial in Women over 60 Living in a Community Dwelling Home

What Was Tested

Researchers studied Parathyroid Hormone (PTH 1-84) in this randomized controlled trial publication.

To evaluate whether fortification of yogurts with vitamin D and calcium exerts an additional lowering effect on serum parathyroid hormone (PTH) and bone resorption markers (BRM) as compared to iso-caloric and iso-protein dairy products in aged white women at risk of fragility fractures.

Who Took Part

The age groups tagged for this paper are middle-aged adults, older adults and people over 80, women only.

Forty-eight women over 60 years (mean age 73.4).

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Random assignment meant chance, not the researchers, decided who got Parathyroid Hormone (PTH 1-84) and who got the comparison, which limits bias.

As a double-blind Parathyroid Hormone (PTH 1-84) study, the assignments were hidden from both participants and investigators until the end.

A time span of 60 years appears in the methods.

A randomized double-blind controlled trial.

Serum changes from baseline (D0) to D28, D56 and D84 in 25OHD, PTH and in two BRM: Tartrate-resistant-acid-phosphatase-isoform-5b (TRAP5b) and carboxy-terminal-cross-linked-telopeptide of type-I-collagen (CTX).

What Was Measured

The subject headings attached to it are Acid Phosphatase, Biomarkers, Bone Resorption, Calcium, Dietary, Cholecalciferol, Collagen Type I and Food, Fortified.

What This Means in Plain Language

The paper is a randomized and double-blind study of Parathyroid Hormone (PTH 1-84) over 60 years.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2015 (The journal of nutrition, health & aging), a journal based in France.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.