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Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study.
Plain-language guide to PMID 25971439 (2016): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 582 participants.
Key Facts
- PMID
- 25971439
- Journal
- Journal of the American Society of Nephrology : JASN
- Year
- 2016
- Study type
- Randomized Controlled Trial
- Authors
- Chonchol M et al. (5 authors)
- DOI
- 10.1681/ASN.2014101009
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The researchers examined the association between yearly 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and FGF23 serum levels and various clinical outcomes using time-dependent Cox regression models with repeated yearly measures and fixed-covariate Cox models with only baseline values after controlling for important clinical covariates in the HEMO study.
Who Took Part
According to the abstract, 582 participants were involved.
The age groups tagged for this paper are middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
What Was Measured
The researchers examined the association between yearly 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and FGF23 serum levels and various clinical outcomes using time-dependent Cox regression models with repeated yearly measures and fixed-covariate Cox models with only baseline values after controlling for important clinical covariates in the HEMO study.
PubMed files the paper under topics including Bacterial Infections, Fibroblast Growth Factor-23, Fibroblast Growth Factors, Heart Diseases, Renal Dialysis, Renal Insufficiency, Chronic and Vitamin D.
Author keywords: chronic hemodialysis, chronic inflammation and epidemiology and outcomes.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 582 participants.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2016 (Journal of the American Society of Nephrology : JASN), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.