Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of lupus (sle), published as a randomized controlled trial.

Vitamin D has an important immunomodulatory effect, but there are no trials that directly address the boosting of serum levels of 25-hydroxyvitamin D (25[OH]D) in juvenile-onset systemic lupus erythematosus (SLE).

The aim of this study was to evaluate the effect of vitamin D supplementation on disease activity and fatigue in juvenile-onset SLE.

Who Took Part

PubMed indexes the participants as teenagers and young adults, both men and women.

Disease activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the European Consensus Lupus Activity Measurement (ECLAM).

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

This study was a randomized, double-blind, placebo-controlled, 24-week trial.

Medications remained stable throughout the study.

Serum levels of 25(OH)D were measured using radioimmunoassay.

Fatigue was assessed using the Kids Fatigue Severity Scale (K-FSS).

What Was Measured

Topics PubMed links to this paper include Age Factors, Biomarkers, Brazil, Cholecalciferol, Dietary Supplements, Fatigue and Glucocorticoids.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in people with lupus (sle).

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2016 (Arthritis care & research), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Lupus (SLE) research.