Fast-digestive protein supplement for ten days overcomes muscle anabolic resistance in healthy elderly men.

What Was Tested

The paper reports a study of Caseins and Leucine, published as a randomized controlled trial.

Adequate protein intake is crucial to maintain muscle protein content in elderly subjects, but quality of dietary proteins should be considered.

Who Took Part

PubMed indexes the participants as older adults, men only.

The researchers investigated the effect of a 10-day adequate-protein (AP) or high-protein (HP) diet together with the protein source as caseins (CAS) or soluble milk proteins (PRO) on specific muscle protein fractional synthesis rates (FSRs) in healthy elderly men (71.8 ± 2.4 yr, n = 31).

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Random assignment meant chance, not the researchers, decided who got Caseins and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received Caseins.

The isotopic study consisted of two periods of 4 h each: a post-absorptive and a postprandial period.

Soluble milk proteins are produced using a membrane process directly from pasteurized milk.

Specific muscle protein FSRs were measured during both postabsorptive and postprandial period using a continuous infusion of l-[1-(13)C]leucine.

What Was Measured

Topics PubMed links to this paper include Beverages, Carbon Isotopes, Caseins, Diet, High-Protein, Dietary Supplements, Digestion and Elder Nutritional Physiological Phenomena.

Author keywords: Elderly, Leucine, Muscle protein synthesis, Sarcopenia and Soluble milk proteins.

What This Means in Plain Language

The paper is a randomized and double-blind study of Caseins and Leucine.

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2016 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: all human trials.