Investigation of Bone Health Subsequent to Vitamin D Supplementation in Children Following Burn Injury.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The objective of this study was to evaluate postintervention incidence of fractures in children during the rehabilitative phase postburn (PB) following participation in a randomized clinical trial of vitamin D supplementation.

Why It Was Studied

The effect of supplemental vitamin D on fracture occurrence following burn injuries is unclear.

Who Took Part

According to the abstract, 39 patients were involved.

PubMed indexes the participants as infants, young children, children and teenagers, both men and women.

Serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, D2, D3, calcitonin, and bone alkaline phosphatase (BAP) measurements were obtained PB day 7, midpoint, discharge, and 1-year PB.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Urinary calcium was obtained PB day 7 and midpoint.

Dual-energy x-ray absorptiometry (DXA) was performed at discharge and 1-year PB.

What Was Measured

Topics PubMed links to this paper include Absorptiometry, Photon, Bone Density, Burns, Causality, Dietary Supplements, Fractures, Bone and Vitamin D.

The authors tagged it with the keywords bone fractures, bone health, pediatrics and vitamin D deficiency.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 39 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.