The Effectiveness of Vitamin B12 for Relieving Pain in Aphthous Ulcers: A Randomized, Double-blind, Placebo-controlled Trial

What Was Tested

Researchers studied Cyanocobalamin (Vitamin B12) in this randomized controlled trial publication.

A randomized, double-blind, placebo-controlled trial was performed with primary care patients.

The intervention group received vitamin B12 ointment for 2 days.

Who Took Part

According to the abstract, 42 patients were involved.

By PubMed's age tags, the people studied were young adults, adults, middle-aged adults, older adults and people over 80, both men and women.

In total, 42 patients suffering from aphthous ulcers participated in the study: 22 were included in the intervention group and 20 in the control group.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Cyanocobalamin (Vitamin B12) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the patients nor the staff measuring them knew who was on Cyanocobalamin (Vitamin B12), so expectations could not easily colour the readings.

Some patients received a placebo instead of Cyanocobalamin (Vitamin B12), giving a reference point.

What Was Measured

A randomized, double-blind, placebo-controlled trial was performed with primary care patients.

The subject headings attached to it are Analgesics, Pain, Stomatitis, Aphthous, Vitamin B 12 and Vitamin B Complex.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 42 patients.

The publication is from 2015 (Pain management nursing : official journal of the American Society of Pain Management Nurses), a journal based in United States.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.