Vitamin D3 supplementation: Response and predictors of vitamin D3 metabolites - A randomized controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Large parts of the population are insufficiently supplied with vitamin D, in particular when endogenous synthesis is absent.

Therefore many health care providers recommend the use of vitamin D supplements.

Who Took Part

The study group was 105 subjects.

By PubMed's age tags, the people studied were young adults, adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and parallel-group study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some subjects received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Groups ran in parallel: each of the subjects stayed in one arm throughout.

The study was conducted as a double-blind, randomized, placebo-controlled parallel trial from January till April 2013.

Circulating levels of vitamin D3 metabolites such as the 25(OH)D3 and the 24,25(OH)2D3, and biomarkers of calcium and phosphate metabolism were quantified.

What Was Measured

Topics PubMed links to this paper include 24,25-Dihydroxyvitamin D 3, Biomarkers, Blood Pressure, Body Mass Index, Calcifediol, Calcium and Cholecalciferol.

Author keywords: 24,25(OH)(2)D(3), 25(OH)D(3), Healthy subjects, Randomized controlled trial and Supplementation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 105 subjects.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2016 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.