Dynamic detection of N-terminal pro-B-type natriuretic peptide helps to predict the outcome of patients with major trauma

What Was Tested

The paper reports a study of BNP (Nesiritide), published as an observational study.

The present study was conducted to investigate the dynamic changes of NT-proBNP in patients with major trauma (injury severity score ≥16), determine whether NT-proBNP could be used as a simple index to predict mortality in major trauma patients.

Why It Was Studied

However, the prognostic value and the dynamic changes of BNP or NT-proBNP in trauma patients remain unclear.

Who Took Part

According to the abstract, 60 patients were involved.

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

This prospective observational study included 60 patients with major trauma.

NT-proBNP levels in patients with traumatic brain injury were compared with those in patients without traumatic brain injury.

How the Study Was Run

Serum NT-proBNP levels were measured on the 1st, 3rd and 7th day after injury The NT-proBNP levels in survivors were compared with those in non-survivors.

An analysis of correlations between NT-proBNP and various factors, including injury severity score, Glasgow coma score, acute physiology and chronic health evaluation II, central venous pressure, creatine kinase-MB, cardiac troponin I and procalcitonin (PCT) was performed.

A comparison of NT-proBNP levels between patients with and without sepsis was also performed at each time point.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Lactic Acid, Multiple Trauma, Natriuretic Peptide, Brain, Peptide Fragments, Predictive Value of Tests and Prognosis.

What This Means in Plain Language

This is an observational study of BNP (Nesiritide) in 60 patients.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2015 (European journal of trauma and emergency surgery : official publication of the European Trauma Society), a journal based in Germany.

More context: the BNP (Nesiritide) compound page, all human trials.