Changes in N-terminal pro-B-type natriuretic peptide and incidence of diabetes: The Multi-Ethnic Study of Atherosclerosis (MESA)

What Was Tested

The paper reports a study of BNP (Nesiritide), published as an observational study.

This study looked at whether the inverse association of circulating N-terminal pro-B-type natriuretic peptide (NT-proBNP) with incident diabetes is modified by changes in NT-proBNP (ΔNT-proBNP) levels.

A Poisson distribution was fitted to determine the incidence density of diabetes, adjusted for age, race, gender, educational attainment, antihypertensive medication, total intentional exercise and plasma IL-6 levels.

Who Took Part

The age groups tagged for this paper are middle-aged adults, older adults and people over 80, both men and women.

How the Study Was Run

Plasma NT-proBNP was assayed at baseline and 3.2 years later (visit 3) in the Multi-Ethnic Study of Atherosclerosis (MESA). ΔNT-proBNP was calculated as NT-proBNP visit3-NT-proBNP baseline.

In the primary analysis (n=3236 without diabetes up to visit 3, followed for a mean of 6.3 years), incidence density was regressed for the following categories of baseline NT-proBNP: (1)<54.4 pg/mL; (2) 54.4-85.9 pg/mL; and (3) 86-54.2 pg/mL.

This was crossed with categories of ΔNT-proBNP as medians (ranges): (1) -6.2 (-131-11.7) pg/mL; (2) 19.8 (11.8-30.1) pg/mL; (3) 44.0 (30.2-67.9) pg/mL; and (4) 111.2 (68.0-3749.9) pg/mL.

What Was Measured

Topics PubMed links to this paper include Asymptomatic Diseases, Atherosclerosis, Cohort Studies, Diabetes Mellitus, Type 2, Incidence, Interleukin-6 and Minnesota.

Author keywords: Change, MESA study, NT-proBNP and Natriuretic peptides.

What This Means in Plain Language

This is an observational study of BNP (Nesiritide).

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (Diabetes & metabolism), a journal based in France.

More context: the BNP (Nesiritide) compound page, all human trials.