Predictive parameters of response to desmopressin in primary nocturnal enuresis

What Was Tested

The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.

The aim of this study was to identify any possible predictive factors to desmopressin response.

Why It Was Studied

Many recent treatment guidelines have advocated the importance of a full noninvasive medical evaluation.

To individualize treatment, special emphasis must be put on recording of the maximum voided volume (MVV) and nocturnal diuresis in a diary or frequency/volume chart.

Who Took Part

The study group was 936 children.

PubMed indexes the participants as young children, children and teenagers, both men and women.

This study is a re-analysis of a prospective, open-label, multinational, phase-IV study evaluating ≤6 months of treatment with desmopressin tablets for children with primary nocturnal enuresis.

The children were enrolled between April 2002 and December 2004 from 86 centers in four countries: UK, Canada, Germany and France.

How the Study Was Run

In design terms this was a randomized and open-label study.

The children were allocated by chance, so the Vasopressin group and the comparison group should start out alike.

Being open-label, the Vasopressin study did not mask who received what.

A total of 936 children were screened; 744 children aged 5-15 years participated in the study.

Of these, 471 children completed the study with 6 months follow-up and recording in a frequency/volume chart.

All children experienced six or more wet nights during the 14-day screening period.

Exclusion criteria were: organic pathology, treatment for enuresis within the past year, previous treatment for enuresis for >4 weeks, diurnal symptoms, renal or central diabetes insipidus and the use of systemic antibiotics or other drugs known to affect desmopressin activity.

The predictive value of number of wet nights a week, fluid intake, daytime voiding frequency and diuresis was investigated by performing a multinomial logistic regression.

What Was Measured

Many recent treatment guidelines have advocated the importance of a full noninvasive medical evaluation.

The subject headings attached to it are Antidiuretic Agents, Deamino Arginine Vasopressin, Nocturnal Enuresis and Urination.

Author keywords: Child, Desmopressin, Oral, Screening and Tablet.

What This Means in Plain Language

The paper is a randomized and open-label study of Vasopressin and Desmopressin in 936 children.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 11 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (Journal of pediatric urology), a journal based in England.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.