Clinical Trial of Vitamin D2 vs D3 Supplementation in Critically Ill Pediatric Burn Patients.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

However, evidence-based guidelines for vitamin D repletion are unknown.

This investigation examined differences between D2 and D3 supplementation on outcome in children with burn injuries.

Who Took Part

The age groups tagged for this paper are infants, young children, children and teenagers, both men and women.

All participants received multivitamin supplementation per standardized clinical protocol.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Assay of total 25-hydroxyvitamin D (D25), 1,25-dihydroxyvitamin D (D1,25), 25-hydroxyvitamin D2 (25-OH-D2), 25-hydroxyvitamin D3 (25-OH-D3), and parathyroid hormone (PTH) was performed at 4 preplanned time intervals (baseline, midpoint, discharge, and 1 year postburn).

Differences in vitamin D status were compared over time and at each specific study interval.

What Was Measured

This investigation examined differences between D2 and D3 supplementation on outcome in children with burn injuries.

The subject headings attached to it are Biomarkers, Burns, Cholecalciferol, Critical Illness, Dietary Supplements, Ergocalciferols and Parathyroid Hormone.

Author keywords: burn injury, pediatrics and vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2017 (JPEN. Journal of parenteral and enteral nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.