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Intrauterine administration of human chorionic gonadotropin does not improve pregnancy and life birth rates independently of blastocyst quality: a randomised prospective study
Plain-language guide to PMID 26141379 (2015): randomized controlled trial study of hCG (human chorionic gonadotropin).
Key Facts
- PMID
- 26141379
- Journal
- Reproductive biology and endocrinology : RB&E
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Wirleitner B et al. (10 authors)
- DOI
- 10.1186/s12958-015-0069-1
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of hCG (human chorionic gonadotropin), published as a randomized controlled trial.
Successful embryo implantation depends on a well-timed maternal-embryonic crosstalk.
Human chorionic gonadotropin (hCG) secreted by the embryo is known to play a key role in this process and to trigger a complex signal transduction cascade allowing the apposition, attachment, and invasion of the embryo into the decidualized uterus.
Who Took Part
The age groups tagged for this paper are young adults and adults, women only.
For both cohorts, patients were randomised to either intrauterine hCG application or to the control group that received culture medium.
How the Study Was Run
The researchers set it up as a randomized study.
The participants were allocated by chance, so the hCG (human chorionic gonadotropin) group and the comparison group should start out alike.
A prospective randomised study was conducted in two settings.
In cohort A, hCG application was performed two days before blastocyst transfer.
In cohort B, the administration of hCG occurred just prior to embryo transfer on day 5.
Clinical outcome was analysed according to blastocyst quality of transferred embryos.
What Was Measured
However, no study has as yet analysed birth rates as final outcome.
The subject headings attached to it are Birth Rate, Blastocyst, Chorionic Gonadotropin, Embryo Transfer, Live Birth and Pregnancy Rate.
What This Means in Plain Language
The paper is a randomized study of hCG (human chorionic gonadotropin).
Results are reported in around 12 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2015 (Reproductive biology and endocrinology : RB&E), a journal based in England.
More context: the hCG (human chorionic gonadotropin) compound page, all human trials.
Our Notes on the Compound
hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.