Vitamin D status is associated with skin autofluorescence in patients with type 2 diabetes mellitus: a preliminary report.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The aim of this study is to investigate the association between vitamin D status and skin autofluorescence in patients with T2DM.

Why It Was Studied

Recently, low vitamin D status has been linked to the progression of type 2 diabetes mellitus (T2DM) and cardiovascular disease.

Who Took Part

The study group was 245 patients.

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

In this preliminary report skin autofluorescence was measured non-invasively with an AGE-reader in 245 patients with T2DM treated with lifestyle advice, metformin and/or sulphonylurea-derivatives.

How the Study Was Run

The design is described as randomized and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

What Was Measured

PubMed files the paper under topics including Cross-Sectional Studies, Diabetes Complications, Diabetes Mellitus, Type 2, Glycation End Products, Advanced, Hypoglycemic Agents, Longitudinal Studies and Metformin.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 245 patients.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (Cardiovascular diabetology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.