Systemic vitamin D supplementation and local bone formation after maxillary sinus augmentation - a randomized, double-blind, placebo-controlled clinical investigation.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

During healing, bone particles are partially resorbed and replaced by the patient's own bone.

Vitamin D plays an essential role in calcium homeostasis and is critical for bone formation and remodeling.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults, both men and women.

Bone cores were harvested at the time of implant placement (6-8 months) for histological analysis.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

What Was Measured

PubMed files the paper under topics including Bone Density, Bone Remodeling, Calcium, Cholecalciferol, Osteogenesis, Sinus Floor Augmentation and Vitamin D.

Author keywords: bone biology, bone graft and osteoclast.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2016 (Clinical oral implants research), a journal based in Denmark.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.