Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as an observational study.

The researchers investigated whether 25-hydroxyvitamin D serum concentration was a modifiable risk factor for early miscarriage.

Why It Was Studied

Miscarriage is the most common negative outcome of pregnancy, and identification of modifiable risk factors is potentially of great importance for public health.

Low vitamin D concentrations in pregnancy are widespread worldwide, and vitamin D deficiency is implicated in immune cell regulation at the feto-maternal interface and several diseases of pregnancy.

Who Took Part

According to the abstract, 1683 women were involved.

The age groups tagged for this paper are young adults and adults, women only.

In a prospective cohort study of 1683 pregnant women donating serum before gestational week 22, the researchers investigated the association between maternal serum concentrations of serum 25-hydroxyvitamin D [25(OH)D] and the risk of subsequent miscarriage (n = 58).

What Was Measured

Miscarriage is the most common negative outcome of pregnancy, and identification of modifiable risk factors is potentially of great importance for public health.

Topics PubMed links to this paper include Abortion, Spontaneous, Denmark, Dietary Supplements, Gestational Age, Pregnancy Trimester, First, Pregnancy Trimester, Second and Risk Factors.

Author keywords: cohort study, endocrinology, miscarriage, spontaneous abortion and vitamin D.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 1683 women.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (The American journal of clinical nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.