Does smoking abstinence influence distress tolerance? An experimental study comparing the response to a breath-holding test of smokers under tobacco withdrawal and under nicotine replacement therapy.

Plain-language guide to PMID 26233827 (2015): double-blind randomized controlled trial of Therapeutic nicotine (patch, non-peptide).

Key Facts

PMID: 26233827
Journal: Psychiatry research
Year: 2015
Study type: Randomized Controlled Trial
Authors: Cosci F et al. (3 authors)
DOI: 10.1016/j.psychres.2015.07.065

What This Study Did, in Plain Language

What Was Tested

Researchers studied Therapeutic nicotine (patch, non-peptide) in this randomized controlled trial publication.

Distress tolerance has been operationalized as task persistence in stressful behavioral laboratory tasks.

According to the distress tolerance perspective, how an individual responds to discomfort/distress predicts early smoking lapses.

Who Took Part

The age groups tagged for this paper are young adults, adults and middle-aged adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the participants and researchers unaware of who received Therapeutic nicotine (patch, non-peptide).

The comparison arm used a placebo, so changes seen with Therapeutic nicotine (patch, non-peptide) could be set against what happens without it.

In the crossover set-up each of the participants took both Therapeutic nicotine (patch, non-peptide) and the comparison in turn, acting as their own control.

What Was Measured

Twenty smokers underwent a breath holding test after the administration of nicotine on one test day and a placebo on another test day.

Topics PubMed links to this paper include Blood Pressure, Breath Holding, Heart Rate, Nicotine, Smoking, Smoking Cessation and Stress, Physiological.

Author keywords: Biological challenge, Discomfort and Stressful behavioral laboratory tasks.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Therapeutic nicotine (patch, non-peptide).

The publication is from 2015 (Psychiatry research), a journal based in Ireland.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.

Our Notes on the Compound

Therapeutic nicotine (patch, non-peptide): Pure nicotine as a signaling tool, separated from smoking and vaping.

Therapeutic nicotine (patch, non-peptide) in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.