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The effects of angiotensin II signaling blockade on platelet activity in subjects with hypertension.
Plain-language guide to PMID 26238113 (2015): randomized controlled trial of Angiotensin II in 33 patients.
Key Facts
- PMID
- 26238113
- Journal
- Current hypertension reviews
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Ahmed N et al. (5 authors)
- DOI
- 10.2174/157340211102150731114920
What This Study Did, in Plain Language
What Was Tested
Researchers studied Angiotensin II in this randomized controlled trial publication.
To investigate the effects of Angiotensin II receptor blockade (ARB) and angiotensin converting enzyme (ACE) inhibition on platelet reactivity in patients with mild to moderate hypertension.
Why It Was Studied
PFA-100 evaluates platelet function (expressed in seconds as closure time, CT) in anti-coagulated whole blood in vitro at high shear rates.
The test cartridge is impregnated with either collagen and epinephrine (Col/Epi) or collagen and ADP (Col/ADP).
Who Took Part
The abstract describes 33 patients taking part.
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized study.
The patients were allocated by chance, so the Angiotensin II group and the comparison group should start out alike.
Normotensive controls (n = 11) were also tested at baseline to standardize PFA-100 CT.
Haematocrit, platelet count and plasma vWF antigen levels were measured.
What Was Measured
PFA-100 evaluates platelet function (expressed in seconds as closure time, CT) in anti-coagulated whole blood in vitro at high shear rates.
The test cartridge is impregnated with either collagen and epinephrine (Col/Epi) or collagen and ADP (Col/ADP).
Topics PubMed links to this paper include Angiotensin II Type 1 Receptor Blockers, Angiotensin-Converting Enzyme Inhibitors, Biomarkers, Hypertension, Life Style, Perindopril and Platelet Function Tests.
What This Means in Plain Language
The paper is a randomized study of Angiotensin II in 33 patients.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2015 (Current hypertension reviews), a journal based in United Arab Emirates.
More context: the Angiotensin II compound page, all human trials.
Our Notes on the Compound
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.