Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome

What Was Tested

This randomized controlled trial paper looks at Peptide YY and Ghrelin.

The researchers compared effects of high-carbohydrate (HC) and high-fat (HF) meals and GH therapy on ghrelin, insulin, peptide YY (PYY), and insulin sensitivity in children with PWS and body mass index (BMI) -matched obese controls (OCs).

Why It Was Studied

The roles of macronutrients and GH in the regulation of food intake in pediatric obesity and Prader-Willi Syndrome (PWS) are poorly understood.

Who Took Part

PubMed indexes the participants as young children, children and teenagers, both men and women.

How the Study Was Run

In design terms this was a randomized and crossover study.

Random assignment meant chance, not the researchers, decided who got Peptide YY and who got the comparison, which limits bias.

In the crossover set-up each of the participants took both Peptide YY and the comparison in turn, acting as their own control.

In a randomized, crossover study, 14 PWS (median, 11.35 y; BMI z score [BMI-z], 2.15) and 14 OCs (median, 11.97 y; BMI-z, 2.35) received isocaloric breakfast meals (HC or HF) on separate days.

Blood samples were drawn at baseline and every 30 minutes for 4 hours.

Mixed linear models were adjusted for age, sex, and BMI-z.

What Was Measured

Topics PubMed links to this paper include Dietary Carbohydrates, Dietary Fats, Ghrelin, Human Growth Hormone, Pediatric Obesity, Peptide YY and Postprandial Period.

What This Means in Plain Language

The paper is a randomized and crossover study of Peptide YY and Ghrelin.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Peptide YY compound page and the Ghrelin compound page, all human trials.