Bilateral Truncal Ligation of the Inferior Thyroid Artery during Bilateral Subtotal Thyroidectomy Causes a Decrease in Parathormone without Clinically Manifest Hypoparathyroidism: A Randomized Clinical Trial

What Was Tested

This randomized controlled trial paper looks at Parathyroid Hormone (PTH 1-84).

However, its effect on parathyroid function has not been evaluated in relation to age, residual and resected thyroid volume.

Who Took Part

According to the abstract, 83 patients were involved.

The age groups tagged for this paper are teenagers, young adults, adults, middle-aged adults, older adults and people over 80, both men and women.

A total of 83 patients were randomized to receive non-BTL or BTL.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Parathyroid Hormone (PTH 1-84) and who got the comparison, which limits bias.

After bilateral resection, the residual thyroid tissue on each side was measured by intra-operative ultrasonography.

Laboratory and clinical examinations were performed the day before operation, intra-operatively and on post-operative days 2 and 5.

The primary outcome measure was the difference in intact parathormone (PTHi) on post-operative day 5.

Secondary outcomes were laboratory-diagnosed hypocalcaemia or hypoparathyroidism and clinically manifest hypoparathyroidism, respectively.

What Was Measured

However, its effect on parathyroid function has not been evaluated in relation to age, residual and resected thyroid volume.

The subject headings attached to it are Arteries, Goiter, Nodular, Hypoparathyroidism, Ligation, Parathyroid Hormone, Postoperative Complications and Thyroid Gland.

What This Means in Plain Language

The paper is a randomized study of Parathyroid Hormone (PTH 1-84) in 83 patients.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2015 (European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes), a journal based in Switzerland.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.