Impact of the Macronutrient Composition of a Nutritional Supplement on Muscle Protein Synthesis Rates in Older Men: A Randomized, Double Blind, Controlled Trial.

What Was Tested

The paper reports a study of Leucine, published as a randomized controlled trial.

The objective of the study was to determine the impact of the macronutrient composition of a nutritional supplement on the postprandial muscle protein synthetic response in older men.

Stable isotope tracer methodology was applied to assess the basal as well as the postprandial muscle protein synthesis rates in the three groups.

Why It Was Studied

An impaired muscle protein synthetic response to feeding likely contributes to muscle loss with aging.

There are few data available on the effect of the macronutrient composition of clinical supplements on the postprandial muscle protein synthetic response in older subjects.

Who Took Part

The abstract describes 45 men taking part.

By PubMed's age tags, the people studied were older adults, men only.

How the Study Was Run

In design terms this was a randomized and double-blind study.

The men were allocated by chance, so the Leucine group and the comparison group should start out alike.

As a double-blind Leucine study, the assignments were hidden from both participants and investigators until the end.

What Was Measured

Topics PubMed links to this paper include Aging, Blood Glucose, Dietary Carbohydrates, Dietary Fats, Dietary Supplements, Food and Insulin.

What This Means in Plain Language

The paper is a randomized and double-blind study of Leucine in 45 men.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: all human trials.