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The effect of 12-wk ω-3 fatty acid supplementation on in vivo thalamus glutathione concentration in patients "at risk" for major depression
Plain-language guide to PMID 26333890 (2015): placebo-controlled randomized controlled trial study of Glutathione.
Key Facts
- PMID
- 26333890
- Journal
- Nutrition (Burbank, Los Angeles County, Calif.)
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Duffy SL et al. (7 authors)
- DOI
- 10.1016/j.nut.2015.04.019
What This Study Did, in Plain Language
What Was Tested
Researchers studied Glutathione in this randomized controlled trial publication.
Oxidative stress may be implicated in the pathophysiology of major depression and can be measured in vivo using proton magnetic resonance spectroscopy via the neurometabolite glutathione (GSH).
The aim of this study was to examine the effect of ω-3 FA supplementation on in vivo GSH concentration in older adults at risk for depression.
Who Took Part
The age groups tagged for this paper are middle-aged adults, older adults and people over 80, both men and women.
Participants underwent magnetic resonance spectroscopy, as well as medical, neuropsychological, and self-report assessments at baseline and after 12 wk of supplementation.
Depressive symptoms were measured using the Patient Health Questionnaire.
How the Study Was Run
The researchers set it up as a randomized and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Glutathione and who got the comparison, which limits bias.
The comparison arm used a placebo, so changes seen with Glutathione could be set against what happens without it.
GSH was measured in the thalamus and calculated as a ratio to creatine.
What Was Measured
Topics PubMed links to this paper include Cognition Disorders, Creatine, Major Depressive Disorder, Dietary Supplements, Fatty Acids, Omega-3, Glutathione and Oxidative Stress.
Author keywords: Magnetic resonance spectroscopy, Major depression, Thalamus and ω-3 fatty acid.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Glutathione.
Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2015 (Nutrition (Burbank, Los Angeles County, Calif.)), a journal based in United States.
More context: the Glutathione compound page, all human trials.
Our Notes on the Compound
Glutathione: The body's main antioxidant.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.