A Pilot Study to Determine if Vitamin D Repletion Improves Endothelial Function in Lupus Patients.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of lupus (sle), published as a randomized controlled trial.

This study was designed to determine the effect size of repleting vitamin D levels on endothelial function in patients with SLE and vitamin D deficiency.

Why It Was Studied

The endothelium is important not only in regulating vascular tone but also in modulating inflammation.

Patients with systemic lupus erythematosus (SLE) have deficits in these endothelial functions.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized and pilot study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.

What Was Measured

Many SLE patients have insufficient levels of vitamin D.

Topics PubMed links to this paper include Cholecalciferol, Dietary Supplements, Endothelium, Inflammation, Lupus Erythematosus, Systemic, Pilot Projects and Vascular Diseases.

What This Means in Plain Language

The paper is a randomized and pilot study of Vitamin D, K2, Magnesium and Zinc in people with lupus (sle).

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (The American journal of the medical sciences), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Lupus (SLE) research.