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Prevention of vitamin D deficiency in children following cardiac surgery: study protocol for a randomized controlled trial.
Plain-language guide to PMID 26353829 (2015): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 62 participants.
Key Facts
- PMID
- 26353829
- Journal
- Trials
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- McNally JD et al. (10 authors)
- DOI
- 10.1186/s13063-015-0922-8
- Registered trial
- NCT01838447
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Vitamin D is a pleiotropic hormone important for the recovery of organ systems after critical illness.
Clinicaltrials.gov Identifier--NCT01838447 Date of registration: 11 April 2013.
Who Took Part
According to the abstract, 62 participants were involved.
By PubMed's age tags, the people studied were infants, young children, children and teenagers, both men and women.
Eligibility requirements include age (>36 weeks, <18 years) and a congenital heart defect requiring cardiopulmonary bypass surgical correction.
How the Study Was Run
The design is described as randomized, double-blind, parallel-group and pilot.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
The primary outcome measure is immediate postoperative vitamin D status, using blood 25(OH)D.
What Was Measured
The subject headings attached to it are Age Factors, Biomarkers, Cardiac Surgical Procedures, Cardiopulmonary Bypass, Clinical Protocols, Dietary Supplements and Heart Defects, Congenital.
What This Means in Plain Language
The paper is a randomized, double-blind and parallel-group study of Vitamin D, K2, Magnesium and Zinc in 62 participants.
Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2015 (Trials), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.