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Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial.
Plain-language guide to PMID 26362661 (2015): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 2435 children.
Key Facts
- PMID
- 26362661
- Journal
- BMJ open
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Somé JW et al. (9 authors)
- DOI
- 10.1136/bmjopen-2015-007828
- Registered trial
- NCT00944281
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).
When zinc is administered with other micronutrients or foods, its effect is also uncertain.
The researchers assessed the effects of different amounts and sources of zinc on the frequency of diarrhoea, malaria, fever and RTI in young children.
Who Took Part
The abstract describes 2435 children taking part.
PubMed indexes the participants as young children and children, both men and women.
This community-based, double-blind, placebo-controlled, cluster-randomised trial of 2435 children 9 months of age was carried out between April 2010 and July 2012 in rural southwestern Burkina Faso.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The children were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
Some children received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
PubMed files the paper under topics including Burkina Faso, Cluster Analysis, Diarrhea, Dietary Supplements, Fever, Incidence and Lipids.
Author keywords: NUTRITION & DIETETICS.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 2435 children.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2015 (BMJ open), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.
Our Notes on the Compounds
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.