Prolonged blood pressure elevation following continuous infusion of angiotensin II-a baroreflex study in healthy humans

What Was Tested

Researchers studied Angiotensin II in the context of low blood pressure and orthostatic hypotension in this clinical study publication.

ANG II interacts with the sympathetic nervous system at central nervous blood pressure-regulating structures, including the baroreflex.

In a blinded crossover design, ANG II or placebo (saline) was infused for a 6-h period in 12 resting normotensive students (6 males, 6 females) raising BP to borderline hypertensive levels.

Who Took Part

PubMed indexes the participants as young adults, both men and women.

How the Study Was Run

The design is described as single-blind, placebo-controlled and crossover.

In this single-blind Angiotensin II study one party knew the assignments and the other did not.

Some participants received a placebo instead of Angiotensin II, giving a reference point.

In the crossover set-up each of the participants took both Angiotensin II and the comparison in turn, acting as their own control.

What Was Measured

In a blinded crossover design, ANG II or placebo (saline) was infused for a 6-h period in 12 resting normotensive students (6 males, 6 females) raising BP to borderline hypertensive levels.

The subject headings attached to it are Adaptation, Physiological, Angiotensin II, Baroreflex, Blood Pressure, Healthy Volunteers, Heart Rate and Infusions, Parenteral.

What This Means in Plain Language

The paper is a single-blind, placebo-controlled and crossover study of Angiotensin II in people with low blood pressure and orthostatic hypotension.

The publication is from 2015 (American journal of physiology. Regulatory, integrative and comparative physiology), a journal based in United States.

More context: the Angiotensin II compound page, Low blood pressure and orthostatic hypotension research.