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A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study
Plain-language guide to PMID 26412463 (2016): double-blind randomized controlled trial study of Cyanocobalamin (Vitamin B12).
Key Facts
- PMID
- 26412463
- Journal
- Calcified tissue international
- Year
- 2016
- Study type
- Randomized Controlled Trial
- Authors
- Swart KM et al. (16 authors)
- DOI
- 10.1007/s00223-015-0059-5
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance, handgrip strength, and risk of falling in elderly subjects in a double-blind, randomized placebo-controlled trial.
Why It Was Studied
Homocysteine-lowering therapy may slow down this decline.
Falls were reported prospectively on a research calendar.
Who Took Part
The age groups tagged for this paper are older adults and people over 80, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The participants were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.
As a double-blind Cyanocobalamin (Vitamin B12) study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with Cyanocobalamin (Vitamin B12) could be set against what happens without it.
The timeline in the abstract includes 2 years.
Physical performance (range 0-12) and handgrip strength (kg) were measured at baseline and after 2 years.
What Was Measured
Intention-to-treat (primary) and per-protocol (secondary) analyses were performed.
Topics PubMed links to this paper include Accidental Falls, Aging, Dietary Supplements, Folic Acid, Hand Strength, Homocysteine and Motor Activity.
Author keywords: Falling, Physical function and Vitamin B12.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) over 2 years.
The publication is from 2016 (Calcified tissue international), a journal based in United States.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.