Prospective associations between vitamin D status, vitamin D-related gene polymorphisms, and risk of tobacco-related cancers.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Their objective was to prospectively study the association between plasma 25-hydroxyvitamin D [25(OH)D] concentrations, vitamin D-related gene polymorphisms, and risk of tobacco-related cancers.

Why It Was Studied

To their knowledge, only one previous epidemiologic study investigated the association between vitamin D status and tobacco-related cancer risk, and no study has focused on vitamin D-related gene polymorphisms.

Who Took Part

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

A total of 209 tobacco-related cancers were diagnosed within the SU.VI.MAX (Supplémentation en vitamines et minéraux antioxydants) cohort (1994-2007) and were matched with 418 controls as part of a nested case-control study.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Tobacco-related cancers (i.e., cancers for which tobacco is one of the risk factors) included several sites in the respiratory, digestive, reproductive, and urinary systems.

Total plasma 25(OH)D was assessed with the use of an electrochemoluminescent assay.

Polymorphisms were determined with the use of a TaqMan assay.

Conditional logistic regression models were computed.

What Was Measured

PubMed files the paper under topics including 25-Hydroxyvitamin D 2, Calcifediol, Case-Control Studies, Cohort Studies, France, Genetic Association Studies and Genetic Predisposition to Disease.

Author keywords: nested case-control study, single nucleotide polymorphisms, smoking status and tobacco-related cancers.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2015 (The American journal of clinical nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.