← Human Trials & Peer-Reviewed Studies
Threshold Effects of Vitamin D Status on Bone Health in Chinese Adolescents With Low Calcium Intake.
Plain-language guide to PMID 26465394 (2015): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 222 adolescents.
Key Facts
- PMID
- 26465394
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Wu F et al. (3 authors)
- DOI
- 10.1210/jc.2015-2849
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Their objective was to determine whether thresholds exist for associations between 25OHD levels and bone outcomes and if low 25OHD levels have adverse effects on bone health.
Why It Was Studied
There is no consensus on the definition of vitamin D deficiency for bone health based on serum 25-hydroxyvitamin D (25OHD) levels.
Who Took Part
The abstract describes 222 adolescents taking part.
PubMed indexes the participants as children and teenagers, both men and women.
The researchers measured serum 25OHD; bone mineral density (BMD) of total body, hip, and lumbar spine (LS); serum PTH; bone alkaline phosphatase (BAP); and tartrate-resistant acid phosphatase 5b (TRAP5b) in 222 healthy adolescents (111 girls, 111 boys).
How the Study Was Run
The researchers set it up as a randomized study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
This is a cross-sectional study.
This study included secondary school students in Beijing, China, aged 12-15 years.
What Was Measured
There is no consensus on the definition of vitamin D deficiency for bone health based on serum 25-hydroxyvitamin D (25OHD) levels.
PubMed files the paper under topics including Alkaline Phosphatase, Beijing, Bone Density, Bone Remodeling, Bone and Bones, Calcium and Calcium, Dietary.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 222 adolescents.
Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2015 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.