Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The primary aim of this study was to determine the effect of zinc supplementation on biochemical markers of bone turnover and growth in girls entering the early stages of puberty.

The secondary aim was to test moderation by race, body mass index (BMI) classification, and plasma zinc status at baseline.

Why It Was Studied

It is unclear whether zinc supplementation can enhance bone health during this rapid period of growth and development.

Who Took Part

The age groups tagged for this paper are children, women only.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Fasting plasma zinc, procollagen type 1 amino-terminal propeptide (P1NP; a bone formation marker), carboxy-terminal telopeptide region of type 1 collagen (ICTP; a bone resorption marker), and insulin-like growth factor I (IGF-I) were assessed at baseline and post-test.

Additional markers of bone formation (osteocalcin) and resorption (urinary pyridinoline and deoxypyridinoline) were also measured.

What Was Measured

PubMed files the paper under topics including Amino Acids, Biomarkers, Bone Development, Bone Remodeling, Collagen Type I, Dietary Supplements and Insulin-Like Growth Factor I.

Author keywords: bone turnover, children and zinc.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (The Journal of nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.