The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a meta-analysis.

The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects.

To assess the study quality, a nine-point scoring system according to the Newcastle-Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points.

Who the Included Studies Covered

PubMed indexes the participants as teenagers, young adults, adults, middle-aged adults and older adults.

The analysed population consisted of 1955 overweight and obese subjects.

How the Review Was Done

The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase.

Thirteen randomized controlled trials were included.

The mean age ranged from 13.6 to 71.7 years.

Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed.

To combine individual study results, a meta-analysis was performed.

What Was Measured

PubMed files the paper under topics including Biomarkers, C-Reactive Protein, Databases, Factual, Dietary Supplements, Interleukin-6, Obesity and Overweight.

Author keywords: Adipokines, Cytokines and Vitamin D.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2016 (European journal of nutrition), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.