Circulating concentrations of endothelin-1 predict coronary heart disease in women but not in men: a longitudinal observational study in the Vara-Skövde Cohort

What Was Tested

The paper reports a study of Endothelin-1, published as an observational study.

Their aim was to investigate whether circulating endothelin-1 levels predict coronary heart disease (CHD) in Sweden.

Why It Was Studied

The vasoconstricting peptide endothelin-1 has been proposed to be a marker of cardiovascular disease.

Who Took Part

The study group was 2005, participants.

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

In 2002-2005, 2816 adult participants (30-74 years) were randomly selected from two municipalities in south-western Sweden.

Cardiovascular risk factors and endothelin-1 levels were assessed at baseline, and incident CHD was followed-up in all participants through 2011.

How the Study Was Run

After exclusion of 50 participants due to known CHD at baseline and 21 participants because of unsuccessful analysis of endothelin-1, 2745 participants were included in the study.

In total, 72 CHD events (52 in men and 20 in women) were registered during the follow-up time.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Coronary Disease, Endothelin-1, Incidence, Kaplan-Meier Estimate, Longitudinal Studies and Multivariate Analysis.

What This Means in Plain Language

This is an observational study of Endothelin-1 in 2005, participants.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (BMC cardiovascular disorders), a journal based in England.

More context: the Endothelin-1 compound page, all human trials.