Vitamin D Supplementation Modulates T Cell-Mediated Immunity in Humans: Results from a Randomized Control Trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Their objective was to determine whether oral vitamin D3 influences T-cell activation in humans with vitamin D deficiency.

Who Took Part

According to the abstract, 38 patients were involved.

PubMed indexes the participants as adults and middle-aged adults, both men and women.

Adults with vitamin D deficiency and untreated pre- or early stage I hypertension were included.

In this ancillary study of 38 patients, the researchers measured CD4+ T-cell activation estimated by intracellular ATP release after stimulation of whole blood with plant lectin phytohemagglutinin collected at baseline (pretreatment) and 2-month follow-up.

How the Study Was Run

The design is described as randomized, double-blind and multicenter.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the patients and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Running at several centres spread the Vitamin D, K2, Magnesium and Zinc study over different clinics and patient groups.

This was a single-center ancillary study within Vitamin D Therapy in Individuals at High Risk of Hypertension, a double-blind, multicenter, randomized controlled trial.

This study was undertaken in a single academic medical center.

What Was Measured

The subject headings attached to it are Adenosine Triphosphate, Cholecalciferol, Cohort Studies, Dietary Supplements, Hypertension, Lymphocyte Activation and T-Lymphocytes.

What This Means in Plain Language

The paper is a randomized, double-blind and multicenter study of Vitamin D, K2, Magnesium and Zinc in 38 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2016 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.