Effect of meal composition on postprandial glucagon-like peptide-1, insulin, glucagon, C-peptide, and glucose responses in overweight/obese subjects

What Was Tested

The paper reports a study of Glucagon, published as a randomized controlled trial.

To examine the effect of a HP versus a HMF meal on GLP-1 response.

Why It Was Studied

Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released in response to food intake.

It is unclear how meals high in protein (HP) and monounsaturated fat (HMF) affect GLP-1 response.

Who Took Part

By PubMed's age tags, the people studied were teenagers, young adults, adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized and crossover study.

Because people in this Glucagon study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Each person switched between Glucagon and the comparison at some point, usually with a gap in between.

Both meals contained the same energy and carbohydrate content.

GLP-1, insulin, glucagon, C-peptide, and glucose were assessed from blood drawn in the fasting and postprandial states.

The effect of meal condition on hormone and glucose responses and appetite ratings were assessed by repeated measures analysis.

What Was Measured

Topics PubMed links to this paper include Appetite, Blood Glucose, Body Mass Index, C-Peptide, Exercise, Glucagon and Glucagon-Like Peptide 1.

The authors tagged it with the keywords Glucagon-like peptide-1, High-monounsaturated fat meal, High-protein meal, Insulin, Meal composition and Obesity.

What This Means in Plain Language

The paper is a randomized and crossover study of Glucagon.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2017 (European journal of nutrition), a journal based in Germany.

More context: the Glucagon compound page, all human trials.