Jejunal feeding is followed by a greater rise in plasma cholecystokinin, peptide YY, glucagon-like peptide 1, and glucagon-like peptide 2 concentrations compared with gastric feeding in vivo in humans: a randomized trial

What Was Tested

Researchers studied Peptide YY and Cholecystokinin (CCK) in this randomized controlled trial publication.

The researchers compared the impact of administering enteral nutrition as either gastric feeding or jejunal feeding on endocrine responses in vivo in humans.

Blood samples were collected during the 12-h postprandial period to assess the rise in plasma glucose, amino acid, and gastrointestinal hormone concentrations.

Why It Was Studied

Jejunal feeding is preferred instead of gastric feeding in patients who are intolerant to gastric feeding or at risk of aspiration.

However, the impact of gastric feeding compared with that of jejunal feeding on postprandial circulating plasma glucose and amino acid concentrations and the associated endocrine response in vivo in humans remains largely unexplored.

Who Took Part

The study group was 12 men.

PubMed tags the participants as men only.

In a randomized, crossover study design, 12 healthy young men (mean ± SD age: 21 ± 2 y) received continuous enteral nutrition that contained noncoagulating proteins for 12 h via a nasogastric tube or a nasojejunal tube placed 30-40 cm distal to the ligament of Treitz.

How the Study Was Run

The design is described as randomized and crossover.

Because people in this Peptide YY study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In the crossover set-up each of the men took both Peptide YY and the comparison in turn, acting as their own control.

What Was Measured

PubMed files the paper under topics including Amino Acids, Blood Glucose, Cholecystokinin, Digestion, Enteral Nutrition, Gastric Mucosa and Glucagon-Like Peptide 1.

Author keywords: gastric feeding, gastrointestinal hormones, jejunal feeding and malnutrition.

What This Means in Plain Language

The paper is a randomized and crossover study of Peptide YY and Cholecystokinin (CCK) in 12 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2016 (The American journal of clinical nutrition), a journal based in United States.

More context: the Peptide YY compound page and the Cholecystokinin (CCK) compound page, all human trials.